They're like any other plug. The electrode gets burnt away with use, so the gap increases. If I remember right, the advice for Iridium plugs is "do not adjust/re-gap"... though I'm not sure why not, so that makes me wonder if I'm correct.
Any road up... when the gap gets too big (not sure what the gap should be) tweak the plug gaps for a bit more use out of them and start saving up for some new ones.
My Iridium plugs (Alfa T/Spark.. maybe used more revs) lasted 60k just about.. but looked very ropey by then. Again, it was still running fine. Plugs can be changed anytime though.. there's no need to wait for a service interval.
Ralf S.