What's made you grumpy today?

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What's made you grumpy today?

I'm not sure the statement that smoking 'causes' cancer is correct, but I am sure that anyone who I susceptible to cancer will make it far more likely if they smoke. Once cancer is present, smoking will make it worse. There are of course some stories about people who smoked all their life and died of natural causes. My grandfather started smoking at 14, smoked unfiltered cigarettes until into his 70s, lived to his early nineties, but then did die of a smoking related illness. Always had yellow fingers and smelt like an ashtray.

Always makes me wonder when I see someone taking a big drag on a cigarette, then becoming almost helpless with coughing. Do they really not see the cause-effect there?
I must admit, I can kinda believe that claim: if what they say is true, tobacco smoke is essentially a cocktail of known carcinogens. I remember watching a TV program about e-cigarettes, and they said that 50% of smokers will die prematurely as a result of their habit. Obviously, there are smokers who live to a ripe old age, and pass away painlessly in their sleep due to age, but I do think that a certain amount of it just comes down to pure luck tbh.
 
From my O-level biology, back in the dark ages, as I understand it, we are all creating cancerous cells every day. But these get killed off immediately.
Our bodies are continually regenerating most of our cells (sadly not teeth) by a good cell dividing into two identical new ones. Sometimes as this happens one or both mutate. These are often cancerous, but usually the 'wrong' ones are weaker, so our bodies kill them off and try again.
Occasionally the 'wrong' cell is stronger, so stays. This can then divide, creating more, and lumps develop. This is why removing the cancerous cells is often a complete cure.
However, our bodies, being complex electro-chemical organisms, may react to the cancerous cells, or the cancerous cells will themselves create chemical imbalances. This can tehn send wrong chemicals around our systems, causing all sorts of mayhem, including causing other cells to create more 'wrong' ones. This is what happens when "the cancer has spread".
Because the cancerous cells are stronger than the correct ones around it, targeting them for treatment is difficult, as any treatment will also target the good cells, killing them too. And, as this can happen anywhere in our body, there are many different cancers, cancer being a generic term.
Some people are more susceptible to cancers than others, which is why we live without developing any. Anyone susceptible can make it more so by smoking. (Other triggers are available)
Other triggers include shock, including unexpected bereavement, excess stress, etc.
So try not to worry, just live each day to the full. Work and other commitments permitting.

Sorry, a bit morbid.
 
From my O-level biology, back in the dark ages, as I understand it, we are all creating cancerous cells every day. But these get killed off immediately.
Our bodies are continually regenerating most of our cells (sadly not teeth) by a good cell dividing into two identical new ones. Sometimes as this happens one or both mutate. These are often cancerous, but usually the 'wrong' ones are weaker, so our bodies kill them off and try again.
Occasionally the 'wrong' cell is stronger, so stays. This can then divide, creating more, and lumps develop. This is why removing the cancerous cells is often a complete cure.
However, our bodies, being complex electro-chemical organisms, may react to the cancerous cells, or the cancerous cells will themselves create chemical imbalances. This can tehn send wrong chemicals around our systems, causing all sorts of mayhem, including causing other cells to create more 'wrong' ones. This is what happens when "the cancer has spread".
Because the cancerous cells are stronger than the correct ones around it, targeting them for treatment is difficult, as any treatment will also target the good cells, killing them too. And, as this can happen anywhere in our body, there are many different cancers, cancer being a generic term.
Some people are more susceptible to cancers than others, which is why we live without developing any. Anyone susceptible can make it more so by smoking. (Other triggers are available)
Other triggers include shock, including unexpected bereavement, excess stress, etc.
So try not to worry, just live each day to the full. Work and other commitments permitting.

Sorry, a bit morbid.



Your knowledge goes well beyond the car world! It's fascinating but scary to look into for me. I've a parent going through all that right now about to start treatment and it's scary to see how fast everything went from normal to now.

God bless science for giving us a fighting chance against it and being able to understand it.

I think the best thing we can all do is learn to live happier, avoid stress and try to be good to ourselves. Sadness, stress and evil cause many of the problems in the world it seems.

Hence my personal preference to go about life with a small cheap car and hit a small practical house. No stress or debt - at least no unnecessary crap anyway...

Where was I going with this?!
 
Your knowledge goes well beyond the car world! It's fascinating but scary to look into for me.
I pick up lots of random bits that seem to stick. Other stuff, sometimes important, don't stick. Sometimes I surprise myself answering TV quiz questions on subjects I really know nothing about. Especially when the questions are about TV Soaps.

I've a parent going through all that right now about to start treatment and it's scary to see how fast everything went from normal to now.

God bless science for giving us a fighting chance against it and being able to understand it.

I think the best thing we can all do is learn to live happier, avoid stress and try to be good to ourselves. Sadness, stress and evil cause many of the problems in the world it seems.

Hence my personal preference to go about life with a small cheap car and hit a small practical house. No stress or debt - at least no unnecessary crap anyway...

Where was I going with this?!

Very sorry to hear about a family member. My best wishes to you all in dealing with that, and I hope it ends well.

You seem to have your head screwed on well for a young man, well done.
 
Everything you said above



The understanding of these things has moved on a lot since the dark ages but some of what you say is correct.

Every day millions of mutations occur in the DNA in our cells and the cells have mechanisms in place to repair and correct these mutations, these are not cancerous and occur all the time every day. If a mutation gets out of hand the next mechanism to kick in causes the cell to kill its self (apoptosis) preventing the mutating cell from dividing or mutating further. Still not cancerous and perfectly normal part of biology. The body's immune system can also attack and destroy cells which have out grown their welcome killing them before they grow any further.

A cancer occurs when all of these mechanisms fail and the cell is able to multiply and grow with the mutation present. As the tumour grows it creates blood vessels to help supply its needs and the needs of the tumour as a whole and depending on the type of tumour, cancerous cells can be carried off in the blood supply to then get stuck and grow else where in the body, lungs liver bones or brain usually but can end up anywhere. This can be quite helpful to some degree because it might not be obvious where the cancer had come from but if there are cancerous cells in the liver they will be able to biopsy these and see what sort of cell they are, they then may find these cancerous cells are actually breast or other types of cell growing in the liver, so the doctors then know where to scan to find the original tumour.

Some people will be genetically disposed to certain types of cancer as certain genes make you more likely to get certain types of cancer. This is also why certain cancers run in families. Angelina Jolie had the BRCA gene that made her highly susceptible to breast cancer, not if but when, which is why she had surgery to prevent the risks of cancers occurring in the future. However as cancers are caused by damage to our genes and DNA exposure to anything that damages the DNA increases your chance of getting cancer. So chemicals in cigarettes damage the DNA, radiation damages the DNA. Viruses are a type of DNA that inserts its self in our DNA and takes control of the cell to make more infecting DNA this is why viruses like HPV lead to cancer. A weakened immune system can lead to cancers as the body is less able to react to cancers, which in the 80s is why a lot of AIDS sufferers would suffer from Kaposi sarcoma.

As we get older, everyone's chance of getting cancer increases as your cells grow older and are less able to repair themselves.

It's not as simple as strong cells or weaker cells , and removing the cell is not always a complete cure because the body can at anytime reproduce the same mutations leading to people who where previously 'cured' having a recurrence of the same cancer.
The more you expose yourself to DNA damage for example sun exposure or smoking, every time you increase your chance of getting cancer just a little bit more. Shock would not be a cause of cancer but if the shock affected the immune system then this might make someone more susceptible.

Treatments like chemotherapy and radiotherapy involve directly targeting with specially adapted chemicals, the cancer cells and killing them with minimal affect to healthy cells. Some chemotherapy agents have no noticeable side effects and some are terrible. Radiotherapy damaged the DNA to the extent that the mutated cells die or are unable to reproduce. Modern medicine is exploring ways to make the immune system recognise the growing cancers as a foreign body and attack it to kill the cells, much like the immune system would attack blood cells from the wrong blood type.

That's by no means a comprehensive explanation of these things but is a fairly accurate reflection of these things.

Both my wife and I work in health care so this is our bread and butter.
 
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It's fascinating but scary to look into for me. I've a parent going through all that right now about to start treatment and it's scary to see how fast everything went from normal to now.



All the best, hopefully it will all go well for a full recovery, if you ever want to ask any questions you can drop me a PM any time.
 
All the best, hopefully it will all go well for a full recovery, if you ever want to ask any questions you can drop me a PM any time.



Thanks. I appreciate it. There's one thing I've learnt about you on this forum, and it's that whether I like it or not you're pretty much spot on. And more fair than I originally thought!

I think understanding that sort of stuff can make it a bit less scary to be honest. Knowing what it is and what it isn't. And being able to dispel the myths etc to be able to make better choices to try and prevent what we can. Even though in this day and age it seems there's a lot of nasty things that are out to get us.

I don't see why humanity can't come together and fight wars against diseases instead of blowing up people and political / religion eske conflict.
 
I pick up lots of random bits that seem to stick. Other stuff, sometimes important, don't stick. Sometimes I surprise myself answering TV quiz questions on subjects I really know nothing about. Especially when the questions are about TV Soaps.



Very sorry to hear about a family member. My best wishes to you all in dealing with that, and I hope it ends well.

You seem to have your head screwed on well for a young man, well done.

My partner lost her mum on January 29th - it's been very tough and grueling on all of us, we have a 5 year old daughter who lover her so much too - this was hard but... at that age, they are kinda like bullet proof, she got upset a few times but she thinks nice things of her Nanny and she has taken it quite well.

This how the timeline was for us...

She had gone for an evening meal with her sister and mum (my partners aunt and nanna)

On her return home from the meal, she had a blackout when getting out of the taxi and landed head first into the pavement, a good few days later she wasnt feeling well at all, for the past 3 weeks she had a cold and felt a little hazy - nothing to moan about though, she was a wonder woman!.

Anyhow, since the black out, she lost feeling down one side of her top half, the doctors turned her away on the Monday morning, said it was most likley a mini stroke and she would be fine in the next few days...

My partner was with her mum, she wasn't having any of this, they complained and took her mum to A&E at the Bradford Royal Infirmary, later that day they did some scans and discovered a mass in her brain.

They where unsure what it was, was told that they would be called in the morning to go back for some more CT scans. the next day - no phone call, they called the hospital, they knew nothing about it and got funny on the phone, they rang back and got someone else who was so helpful and apologetic, they said come in first thing in the morning, we have booked you in for your scans etc.

Next day (wednesday) she went for some more CT's, they confirmed it was definatley a Mass that was growing rapidly, they referred her to a specialist team in Leeds at the Leeds General.

Friday came, she went to Leeds General, had more tests, an MRI etc then they where told the very bad news, her mum had a Primary Stage 4 GBM (Glioblastoma Multiform) one of the worst cancer's for spreading and it was stage 4.

They advised that it was too far down in the brain to operate and that they could do nothing about it, they offered to do a biopsy to confirm it was actually what they had said it was however, they did advise not have this done as the tumor was so far down on the frontal lobes etc that it would worsener the quality of life she had left (as it was not curable, not at this stage 4) and the consultant also advised of how strong he felt about the diagnosis already given.

In the end, the decision was not to have the biopsy as it wasnt going to cure anything and would of ruined most of what life was left.

Since that day - just over a week after they found a mass (quite out of the blue too...) she had been told she has around 2 months left.

From that day - things went down hill very very quickly, so from around 2nd december things changed rapidly and she sadly left us on January 29th.

Cancer is terrible, its in-humane, i would not wish it on anyone what-so-ever.
The damage it causes leaves ever lasting worry, doubt and all sorts.

It's quite Ironic that I work for Macmillan Cancer! however, i dont work in direct services, fund raising or support line, I work in the IT operations department providing support to the Macmillan domain.

Me and My partner are hoping to do some fundraising this year and I may even consider changing my role for one in the fundraising support teams (for various reasons, its not about the money as it would be a pay cut) but hey ho... this company is wonderful and has provided much needed support to me, my partner and also my daughter!.

Can't thank them enough.

End of my little story, just some thoughts for you all - live life to the full and dont worry about next week, next month, next year - you could be gone within weeks of a disease or the next morning crossing the road, value what you have got, cherish the ones you love and be nice to people!
 
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Dtimmins,
thank you very much for sharing what is happening with you and your family.
It is important to be reminded of truly important things, love , kindness, tolerance etc
Best wishes to all of you,
Jack.
 
I suppose if people lived forever and couldn't die then the beauty and importance of life wouldn't be so strong. It's how fragile it actually is that makes it so important as to what we do and who we are whilst we do live!



If you have all of time to do anything you want, then what's the hurry to do anything at all ?

The fact we're all on a time restriction means we have a need to get things done before we go.
 
Dtimmins,
thank you very much for sharing what is happening with you and your family.
It is important to be reminded of truly important things, love , kindness, tolerance etc
Best wishes to all of you,
Jack.

Thank you for those kind words.

A quick quote from new team leader, health is wealth!

Best wishes to everyone.
 
Very sad.

However, the whole distressing development was relatively fast, if that can be any slight comfort.

Brain tumours come, to be very simplistic, in two forms, one might be contained by the meninges, the other is very aggressive.

We have to cope, and this is hard. Children who see animals regularly and observe them being born, growing and then dying, often manage human traumas better because they develop an innate understanding of the cycle of life. And it important that children move forward and don't get stuck grieving.

I'm very sorry for all of you. We all wonder how it will end and none of us knows. And when we do know, as far as I see it, the sooner the better.

Joy, grief, misery, new beginnings...life. Death. And this is why the ancient measures of our short time here: marriage, birth and death need to be acknowledged and revered.

All the very best to you all.
 
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AS someone, can't remember who, said to me when I was a hell of a lot younger, there are only two things that we cannot change in life. we are born and at some point we will die...in the meanwhile we act like swans, serene above water but paddling like hell to stay afloat !
 
My partner lost her mum on January 29th - it's been very tough and grueling on all of us, we have a 5 year old daughter who lover her so much too - this was hard but... at that age, they are kinda like bullet proof, she got upset a few times but she thinks nice things of her Nanny and she has taken it quite well.

My grandad also lost his battle with cancer on the 29th of January. He was originally diagnosed with prostate cancer late October/early November, and as investigation progressed, it was discovered that he actually had it in 6 different places. It's now just over months since he left us, and whilst we were never that close, I still can't believe he's actually gone.
 
AutoTrader Ad:

"One lady owner since new"..

Sellers Expectation: People will think the car was really well looked after, clean and never pushed or driven harshly....

Harsh Reality: The car probably wasn't serviced... burnt out clutch. Dents, bent back bumper.. Original oil, empty coolant tank.. children's vomit stains.. God knows what else..

I just was thinking, it's funny how they reckon that's a better thing for buyers to know.. hmmm

Perhaps not in all cases
 
AutoTrader Ad:

"One lady owner since new"..

Sellers Expectation: People will think the car was really well looked after, clean and never pushed or driven harshly....

Harsh Reality: The car probably wasn't serviced... burnt out clutch. Dents, bent back bumper.. Original oil, empty coolant tank.. children's vomit stains.. God knows what else..

I just was thinking, it's funny how they reckon that's a better thing for buyers to know.. hmmm

Perhaps not in all cases

It depends I bought a two lady owner punto once and it was immaculately kept. The first owner was the wife of the dealer principal so it had every option and religious servicing

My Suzuki on the other hand was flogged and crashed..and had missed it's first service. Took 2 years and a lot of warranty work, and trip to a bodyshop to undo what the first owner did.
 
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