The weight of a wheel only makes a slight difference. The main problem is the larger diameter of the tyre. The larger diameter in effect raises the gear ratio. The example given is a 185/45 R15 tyre versus the standard 165/55 R13 tyre. The 165/55 R13 tyre is 36mm smaller in diameter than the 185/45 R15 tyre. This may not seem much, but for the same engine speed your road speed will be ~7% higher e.g if you were doing 3000rpm at 70mph with 165/55 13, with 185/45 R15 at 3000rpm you'll be doing 75mph or so.
This increase in tyre size is fine on larger cars with enough hp (and more importantly torque) to pull with the increased gear ratio and make use of the extra top speed gained. However on low hp/torque cars like a cinqucento it will make a noticeable difference to acceleration but without the gains as the car won't have enough power to make use of the extra top speed.
As an example, when I used to drag race my old Clio I changed from 15" front wheels with 195/50 15 tyres to 13" front wheels with 215/50 13 tyres. Back to back tests put showed that the smaller front wheels gave around a 0.4 second advantage.
Also as an aside. A cinq on 15s must handle awfully. Most aftermarket alloy wheels weigh more than OEM steelies. The extra unsprung weight will have a massive affect on the handling.
I've never owned a cinq but i'd stick to 13s or 14s if I did. Theres always the fact that they'll look a lot more balanced rather than like a roller skate.
Matt