It's not that R134A and air "dont like one another" , they're quite happy to co exist and R134A is non toxic, non-flammable and non-corrosive.
It's simply that you don't want what is in air (ie moisture, oxygen and noncondensable gases) circulating around your air con system. That's why a system is evacuated before refilling, to take out as much of everything, not just air, not just moisture but everything
A system is pressure checked with dry Nitrogen because it's cheap, it has no oxygen, it cleans the system through and helps get rid of moisture
More injuries are caused by inexperienced and untrained persons putting unregulated Nitrogen straight from the bottle into their aircon system. 3000psi bottle pressure into a system that operates at a tenth of that. Boom! Plenty of leaks now to investigate once they put your body parts back together again. Or someone, somehow connects a refill can to the high pressure side. Result- exploding refill can. Shouldn't be possible as they're different size fittings but hey ho
Interesting that R134A is planned to be phased out in 2011. Ozone friendly yes but not so good for global warming apparently