My initial reaction is to say don't go anywhere near them - gear oil additives that is. If you think about it I think most work by introducing some extreme pressure substance, Like the Molybdenum Disulfide in Molyslip products and this, theoretically, gives the gearbox a big problem because the synchromesh cones rely on a carefully worked out amount of friction to work properly. This is all very carefully calculated to work correctly with the lubricant specified by the manufacturer so NEVER put any in a gearbox which is working well.
Then I read Panda Nut's post about Molyslip Gearbox additive and I remembered that I'd stuck it in my old Anglia's gearbox way back maybe 50 years ago? when it had worn layshaft bearings and it did indeed quieten it down a lot until I had time to rebuild the box. So, if the box is knackered anyway, why not see if you can make it run just a little longer by feeding it one of these "brews" - You're going to have to rebuild it anyway in the near future.
On reflection though the Anglia had a very simple old type gearbox, much more "agricultural" when compared to what we have today. So I wouldn't use additives in either the engine or gearbox of a modern car - and absolutely not in an automatic.
Fuel additives are perhaps a slightly different prospect and might be of limited efficacy in certain circumstances, but there is a small voice in the back of my head which is muttering "Snake Oil" in my ear, just like Jim above.